Arcane

In the opening scenes, young Vi and Powder (Jinx) witness the aftermath of a brutal conflict, with their parents' corpses shown. Later, two children die in one episode, including a girl whose head is implied to be cut off (off-screen, but with a visible pool of blood) and another child dying after a long fall. Violence involves extensive punching, kicking, and the use of guns, blades, and explosives.

A heterosexual sex scene between characters Jayce and Mel is depicted in Season 1, where sexual activity is implied without explicit nudity. In Season 2, the sapphic relationship between Vi and Caitlyn becomes explicit with a depicted sex scene, where the act is shown without full nudity. Background scenes in the Undercity also suggest the presence of prostitution.

Characters use strong curse words such as 'f*ck,' 'sh*t,' 'p*ss,' and 'a*s' frequently in dialogue. The use of such language is not isolated but is a consistent element of the series' mature dialogue.

Silco, a primary antagonist, is deeply involved in the production and distribution of 'Shimmer,' an illicit substance that causes physical mutations and addiction in its users, becoming a major source of power and conflict in Zaun. This drug directly impacts many of the Undercity's inhabitants and drives key plot points. The devastating effects of Shimmer addiction are depicted through various characters, highlighting its destructive nature.