American Dad!

Roger, a main character, is identified as a 'pansexual character' and a 'fey pansexual alcoholic non-human' who engages in sexual relationships, including with Klaus. Stan's neighbors, Greg Corbin and Terry Bates, are an openly gay couple who become parents via surrogacy. In 'Surro-Gate' (Season 3, Episode 8), Stan attempts to kidnap their child to 'prove that gays shouldn't have children,' which ultimately backfires. The episode 'Lincoln Lover' (Season 3, Episode 4) features Stan's involvement with the Log Cabin Republicans and a musical number titled 'We're Red and We're Gay,' and was nominated for a GLAAD award. In 'LGBSteve' (Season 10, Episode 10), Steve joins a roller derby team, leading to discussions about gender identity and the possibility of being 'a lesbian in a boy's body.' The team members are accepting of Steve's exploration of identity.

Scenes include graphic depictions such as the reaction 'oh my god blood holy fuck' to a violent event. Roger sells a senator's daughter to drug dealers who then threaten to 'shoot him in the head' when he cannot pay them. Hayley accidentally paralyzes Stan after firing a gun she believed was loaded with blanks. The show's content has included themes extreme enough to be cited as reasons for potential indefinite blocking on a fan wiki, such as 'graphic or sexually explicit imagery uploaded, repeated violations of policy, death threats'.

Francine expresses being 'cool with a threesome with Scarlett Johansson.' Linda Memari, a neighbor, is depicted as a 'closeted lesbian' or 'bisexual' who kisses Francine in 'Not Particularly Desperate Housewives' (Season 1, Episode 16) and later attempts to hit on her at a bar. Roger's personas frequently involve sexually suggestive behavior and references to his varied sexual experiences. In one episode, Francine joins a group of housewives who cheat on their husbands.

Francine says, 'Just look at that fucker with cucumbers on his eyes!' and 'Oh, I will fucking chop his head in two!' with 'fucker' and 'fucking' being bleeped in Fox versions, indicating strong language. Steve exclaims 'Holy fuck!' in 'Bush Comes to Dinner' (Season 2, Episode 10), which was muted on Fox. Roger's dialogue includes phrases like 'Shit! Shit! Dammit! We're so ----ing late!' The use of 'fuck,' 'motherfuckers,' 'goddamn,' 'asshole,' 'shitbags,' and 'dick' are noted as muted in Fox versions across various episodes in early seasons.

Roger is explicitly described as an 'alcoholic' and a 'heroin lover' who 'use[s] it sometimes'. He is depicted taking '40 hits of ecstasy' and using amphetamines, leading to chaotic situations. Francine is involved in a scene where Stan 'brings in Whitney Houston to sing a private apology performance for some cocaine.' Roger sells the Senator's daughter to drug dealers after going 'doing drugs with her.' Stan is also shown at times becoming a 'drunk watching day time TV.'

The series includes scenes of graphic violence and implied death threats, such as Roger being told 'take this fool outside and shoot him in the head' by drug dealers. Roger's character frequently exhibits 'freakish grossness, outrageous malice,' and can be genuinely cruel, creating disturbing situations. The episode 'Threat Levels' was temporarily banned from Adult Swim in 2020 due to its theme of quarantine being too sensitive during the COVID-19 pandemic, highlighting its capacity for intense thematic content. The show often features cynical and morally challenging scenarios.

Hayley is consistently portrayed as a 'left-wing activist' who 'knows just how to push her father's buttons,' often rebelling against Stan's conservative views. Roger routinely manipulates, lies to, and disobeys the Smith family, demonstrating 'depraved, devious, and cruel' behavior with 'no limits on his shocking and brazen ways.' Roger once convinced Steve that he was adopted. Francine joining a group of housewives who cheat on their husbands is an act of rebellion and disrespect within her marriage.